Going back to the start
I know we've all heard this song to death, but I really like this version of Coldplay's The Scientist, performed by Aimee Mann. There's something both refreshing for both the song (which is by far my favorite from A Rush of Blood to the Head) and for Aimee Mann, who I think stumbled a bit on her last album. I love this song, because it's almost surprising it hasn't been written before; it's so simple and can kill you on the right (or wrong?) day. I also give kudos to Mann for taking such a recent radio hit and making it work so well.
This is available on the almighty iTunes and on the bonus disc of Lost In Space.